Abstract: Objective Through the detections of serum soluble myeloid cell trigger receptor 1 (sTREM-1) and vitamin D3 (VitD3) levels in senile pneumonia patients, to investigate the relations of sTREM-1 and VitD3 with senile pneumonia, and to provide the reference for clinical diagnosis and treatment. Methods A total of 63 patients with senile pneumonia were enrolled, and 30 healthy subjects were enrolled as control group.sTREM-1 was determined by enzyme-linked immunosorbent assay (ELISA), and electrochemiluminescence was used to determine serum level of VitD3. The results were analyzed comparatively between the 2 groups. Results The sTREM-1 in senile pneumonia group [(234.80±68.90)pg/mL] was significantly higher than that in control group[(74.20±41.20)pg/mL] with statistical significance (P<0.01).VitD3 level in senile pneumonia group [(18.92±7.27)pg/mL] wassignificantly lower than that in control group[(33.75±9.28)pg/mL] with statistical significance (P<0.05). The areas under receiver operating characteristic (ROC) curve were 0.916 for sTREM-1 and 0.897 for VitD3. Conclusions VitD3 and sTREM-1 are good indicators for the diagnosis of senile pneumonia.

Key words: Soluble myeloid cell trigger receptor 1, Vitamin D3, Senile pneumonia