[1]Feng S，Jacobsen SE，Reik W，et al.Epigenetic reprogramming in plant and animal development[J].Science，2010，330(6004):622-627.[2]Niehrs C. Active DNA demethylation and DNA repair[J].Differentiation，2009，77(1):1-11.[3]Wu SC，Zhang Y. Active DNA demethylation: many roads lead to Rome[J]. Nat Rev Mol Cell Biol，2010，11(9):607-620.[4]Zhu JK. Active DNA demethylation mediated by DNA glycosylases[J]. Annu Rev Genet，2009，43:143-166.[5]Gehring M，Reik W，Henikoff S. DNA demethylation by DNA repair[J].Trends Genet，2009，25(2):82-90.[6]Popp C，Dean W，Feng S，et al.Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency[J].Nature，2010，463(7284):1101-1105.[7]Bhutani N，Brady J，Damian M，et al. Reprogramming towards pluripotency requires AID-dependent DNA demethylation[J]. Nature，2010，463(7284):1042-1047.[8]Tahiliani M，Koh KP，Shen Y，et al.Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1[J].Science，2009，324(5929):930-935.[9]Ito S，D′Alessio AC，Taranova OV，et al.Role of Tet proteins in 5mC to 5hmC conversion，ES-cell self-renewal and inner cell mass specification[J].Nature，2010，466(7310):1129-1133.[10]Okada Y，Yamagata K，Hong K，et al.A role for the elongator complex in zygotic paternal genome demethylation[J].Nature，2010，463(7280):554-558.[11]Hu XV，Rodrigues TM，Tao H，et al.Identification of RING finger protein 4(RNF4) as a modulator of DNA demethylation through a functional genomics screen[J]. Proc Natl Acad Sci USA，2010，107(34):15087-15092.[12]Rai K，Huggins IJ，James SR，et al.DNA demethylation in zebrafish involves the coupling of a deaminase，a glycosylase，and gadd45[J].Cell，2008，135(7):1201-1212.[13]Hajkova P，Jeffries SJ，Lee C，et al.Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway[J].Science，2010，329(5987):78-82.[14]Jin SG，Guo C，Pfeifer GP，et al. GADD45A does not promote DNA demethylation[J]. PLoS Genet，2008，4(3): e1000013.[15]Métivier R，Gallais R，Tiffoche C，et al.Cyclical DNA methylation of a transcriptionally active promoter[J]. Nature，2008，452(7183):45-50.[16]Gehring M，Huh JH，Hsieh TF，et al.DEMETER DNA glycosylase establishes MEDEA polycomb gene self-imprinting by allele-specific demethylation[J].Cell，2006，124(3):495-506.[17]Ortega-Galisteo AP，Morales-Ruiz T，Ariza RR，et al. Arabidopsis DEMETER-LIKE proteins DML2 and DML3 are required for appropriate distribution of DNA methylation marks[J]. Plant Mole Biol，2008，67(6):671-681.[18]Delker RK，Fugmann SD，Papavasiliou FN.A coming-of-age story: activation-induced cytidine deaminase turns 10[J].Nat Immunol，2009，10(11):1147-1153.[19]Wu H，D′Alessio AC，Ito S，et al.Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells[J].Genes Dev，2011，25(7):679-684.[20]Maul RW，Gearhart PJ.AID and somatic hypermutation[J]. Adv Immunol，2010，105:159-191.[21]Kriaucionis S，Heintz N.The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain[J].Science，2009，324(5929): 929-930.[22]Wu H，D′Alessio AC，Ito S，et al.Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells[J].Nature，2011，473(7347):389-393.[23]Ficz G，Branco MR，Seisenberger S，et al.Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation[J].Nature，2011，473(7347):398-402.[24]Guo JU，Su Y，Zhong C，et al. Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain[J].Cell，2011，145(3):423-434.[25]He YF，Li BZ，Li Z，et al.Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA[J].Science，2011，333(6047):1303-1307.[26]Wossidlo M，Arand J，Sebastiano V，et al.Dynamic link of DNA demethylation，DNA strand breaks and repair in mouse zygotes[J].EMBO J，2010，29(11):1877-1888.[27]Otero G，Fellows J，Li Y，et al.Elongator，a multisubunit component of a novel RNA polymerase Ⅱ holo-enzyme for transcriptional elongation[J].Mol Cell，1999，3(1):109-118.[28]Petrakis TG，Wittschieben B，Svejstrup JQ.Mole-cular architecture，structure-function relationship，and importance of the Elp3 subunit for the RNA binding of holo-elongator[J].J Biol Chem，2004，279(31):32087-32092.[29]Sofia HJ，Chen G，Hetzler BG，et al.Radical SAM，a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms:functional characterization using new analysis and information visualization methods[J].Nucleic Acids Res，2001，29(5):1097-1106.[30]Rosemary Siafakas A，Richardson DR. Growth arrest and DNA damage-45alpha(GADD45alpha)[J].Int J Biochem Cell Biol，2009，41(5):986-989. [31]Carrier F，Georgel PT，Pourquier P，et al. Gadd45，a p53-responsive stress protein，modifies DNA accessibility on damaged chromatin[J].Mol Cell Biol，1999，19(3):1673-1685. [32]Zhan Q. Gadd45a，a p53- and BRCA1-regulated stress protein，in cellular response to DNA damage[J].Mutat Res，2005，569(1):133-143.[33]Barreto G，Schfer A，Marhold J，et al. Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation[J].Nature，2007，445(7128):671-675.[34]Zhang RP，Shao JZ，Xiang LX.GADD45A plays an essential role in active DNA demethylation during terminal osteogenic differentiation of adipose-derived mesenchymal stem cells[J].J Biol Chem，2011，286(47):41083-41094.[35]Doi A，Park IH，Wen B，et al.Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells，embryonic stem cells and fibroblasts[J].Nat Genet，2009，41(12):1350-1353.[36]Irizarry RA，Ladd-Acosta C，Wen B，et al.The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores[J].Nat Genet，2009，41(2):178-186.[37]Ateeq B，Unterberger A，Szyf M，et al.Pharmacological inhibition of DNA methylation induces proinvasive and prometastatic genes in vitro and in vivo[J].Neoplasia，2008，10(3):266-278.
