Objective To investigate the relations of C-reactive protein(CRP),neutrophil,eosinophil,neutrophil-to-lymphocyte ratio(NRL),cholinesterase,albumin(Alb) and vitamin D with the long-term mortality in patients with chronic obstructive pulmonary disease(COPD). Methods A total of 120 COPD patients in Luoding People's Hospital from January 2015 to January 2017 were enrolled and followed up for 24 months. The subjects were classified into long-term death group(17 cases) and survival group(89 cases). The levels of CRP,neutrophil,eosinophil,NRL,cholinesterase,Alb and 25-hydroxyvitamin D [25(OH)D](vitamin D) between the 2 groups were compared. Logistic analysis was used to evaluate the relations between the blood indicators and long-term mortality,and the predictive value of the blood indicators was analyzed by receiver operating characteristic(ROC) curve analysis. Results The levels of CRP,neutrophil,eosinophil and NRL in long-term death group were higher than those in survival group(P<0.05),and the cholinesterase,Alb and 25(OH)D levels were lower than those in survival group(P<0.05). CRP,neutrophil,eosinophil,NRL,cholinesterase,25(OH)D and Alb were independent risk factors for predicting long-term mortality in COPD patients(odds ratios were 1.23,0.99,1.45,2.75,1.30,1.08 and 0.59,respectively)(P<0.05). The sensitivities and specificities of the 7 indicators had no statistical significance(P>0.05),and the area under curve(AUC) of NRL was bigger than those of the other 6 indicators(P<0.05). Conclusions CRP,neutrophil,eosinophil,NRL,cholinesterase,Alb and 25(OH)D have positive significance in predicting the long-term mortality of COPD,and NRL is a significant predictive indicator.