未成熟血小板比率在异基因造血干细胞移植预测血小板植入中的价值

doi:10.3969/j.issn.1673-8640.2020.07.005

检验医学 ›› 2020, Vol. 35 ›› Issue (7): 651-654.DOI: 10.3969/j.issn.1673-8640.2020.07.005

未成熟血小板比率在异基因造血干细胞移植预测血小板植入中的价值

李勇, 施圆圆, 朱国庆, 杨佳彧, 夏永辉, 茹永新, 杨栋林

中国医学科学院血液病医院（中国医学科学院血液学研究所）实验血液学国家重点实验室国家血液病临床医学研究中心,天津 300020

收稿日期:2019-05-18 出版日期:2020-07-30 发布日期:2020-08-04
作者简介:null
作者简介：李勇,男,1983年生,主管技师,主要从事临床检验工作。
基金资助:
中国医学科学院医学与健康科技创新工程项目（2016-I2M-3-023）

Prediction of platelet implantation by immature platelet ratio in allogeneic stem cell transplantation

LI Yong, SHI Yuanyuan, ZHU Guoqing, YANG Jiayu, XIA Yonghui, RU Yongxin, YANG Donglin

State Key Laboratory of Experimental Hematology,National Clinical Research Center for Blood Diseases,Institute of Hematology and Blood Diseases Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Tianjin 300020,China

Received:2019-05-18 Online:2020-07-30 Published:2020-08-04

摘要/Abstract

摘要：

目的研究未成熟血小板比率（IPF）指标预测异基因造血干细胞移植（allo-SCT）治疗时血小板（PLT）植入成功的意义。方法检测35例allo-SCT患者外周血PLT、IPF及未成熟血小板绝对值（A-IPF）,采用这3项指标预测allo-SCT治疗时PLT植入成功的时间。结果 IPF判断移植患者PLT植入的时间比PLT提前1~3 d,A-IPF可以起到很好的补充作用。结论 IPF和A-IPF可更早预测PLT植入时间,可作为临床评价allo-SCT后PLT植入新的指标。

关键词: 未成熟血小板比率, 未成熟血小板绝对值, 异基因造血干细胞移植

Abstract:

Objective To study the prediction role of immature platelet ratio（IPF） for platelet（PLT） implantation during allogeneic stem cell transplantation（allo-SCT）. Methods A total of 35 allo-SCT cases were enrolled. The PLT count,IPF and the absolute value of immature platelet（A-IPF） in peripheral blood were determined. These parameters were used to predict the success time of PLT implantation during allo-SCT. Results IPF was 1-3 d earlier than PLT count in predicting PLT implantation,and A-IPF could play a good complementary role. Conclusions IPF and A-IPF can predict the time of PLT implantation earlier,which can be used as new parameters for the clinical evaluation of PLT implantation after allo-SCT.

Key words: Immature platelet ratio, Absolute value of immature platelet, Allogeneic stem cell transplantation

中图分类号:

R446.1

李勇, 施圆圆, 朱国庆, 杨佳彧, 夏永辉, 茹永新, 杨栋林. 未成熟血小板比率在异基因造血干细胞移植预测血小板植入中的价值[J]. 检验医学, 2020, 35(7): 651-654.

LI Yong, SHI Yuanyuan, ZHU Guoqing, YANG Jiayu, XIA Yonghui, RU Yongxin, YANG Donglin. Prediction of platelet implantation by immature platelet ratio in allogeneic stem cell transplantation[J]. Laboratory Medicine, 2020, 35(7): 651-654.

图/表 4

参考文献 18

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样本	XE-2100		XN-9000
样本	PLT计数/ （×10⁹/L）	CV/%	PLT计数/ （×10⁹/L）	CV/%
质控品
1	63.6±2.6	4.09	93.5±1.9	2.03
2	232±5.8	2.50	257.8±4.6	1.78
3	539±5.5	1.00	571.2±5	0.88
AA
1	5.6±1.1	19.6	4.2±0.5	11.90
2	9.3±1.8	19.4	8.1±0.8	9.90
ITP
1	37.1±1.7	4.60	37.6±0.6	1.60
2	21.8±1.2	5.50	22.6±0.9	4.00

样本	XE-2100		XN-9000
样本	PLT计数/ （×10⁹/L）	CV/%	PLT计数/ （×10⁹/L）	CV/%
质控品
1	63.6±2.6	4.09	93.5±1.9	2.03
2	232±5.8	2.50	257.8±4.6	1.78
3	539±5.5	1.00	571.2±5	0.88
AA
1	5.6±1.1	19.6	4.2±0.5	11.90
2	9.3±1.8	19.4	8.1±0.8	9.90
ITP
1	37.1±1.7	4.60	37.6±0.6	1.60
2	21.8±1.2	5.50	22.6±0.9	4.00

未成熟血小板比率在异基因造血干细胞移植预测血小板植入中的价值

Prediction of platelet implantation by immature platelet ratio in allogeneic stem cell transplantation

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Metrics

样本编号	中性粒细胞绝对数≥ 0.5×10⁹/L	IPF> 3.0%	A-IPF >0.2×10⁹/L	PLT计数≥ 20×10⁹/L	提前预测天数
样本编号	中性粒细胞绝对数≥ 0.5×10⁹/L	IPF> 3.0%	A-IPF >0.2×10⁹/L	PLT计数≥ 20×10⁹/L	IPF	A-IPF
1	16	15	14	16	1	2
2	13	12	11	12	0	1
3	11	10	9	12	2	3
4	11	9	9	12	3	3
5	12	11	8	12	1	4
6	19	19	19	20	1	1
7	11	9	7	12	3	5
8	16	16	15	18	2	3
9	14	16	11	12	–4	1
10	32	31	31	32	1	1
11	16	12	11	13	1	2
12	12	13	11	12	–1	1
13	22	20	20	22	2	2
14	14	14	12	15	1	3
15	18	14	12	17	3	5
16	27	39	38	39	0	1
17	11	12	11	15	3	4
18	18	21	20	20	–1	0
19	13	12	9	15	3	6
20	14	13	13	13	0	0
21	15	13	12	14	1	2
22	15	18	17	20	2	3
23	11	12	11	14	2	3
24	12	12	10	14	2	4
25	15	15	15	17	2	2
26	14	14	13	15	1	2
27	11	11	10	11	0	1
28	15	16	16	18	2	2
29	11	12	11	13	1	2
30	18	18	17	21	3	4

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