检验医学 ›› 2017, Vol. 32 ›› Issue (8): 668-670.DOI: 10.3969/j.issn.1673-8640.2017.08.002

• 临床应用研究·论著 • 上一篇    下一篇

血小板参数和骨髓巨核细胞计数、分类在May-Hegglin异常疾病中的应用研究

高峰, 张宏杰, 刘瑞芳, 李丽, 杨磊, 刘立国, 闫国艳   

  1. 遵化市人民医院,河北 遵化 064200
  • 收稿日期:2016-05-26 出版日期:2017-08-30 发布日期:2017-09-01
  • 作者简介:null

    作者简介:高 峰,男,1976年生,学士,副主任技师,主要从事细胞形态学诊断研究。

  • 基金资助:
    唐山市科学技术研究与发展计划(15130240a)

Platelet parameters and bone marrow megakaryocyte count and classification in May-Hegglin anomaly

GAO Feng, ZHANG Hongjie, LIU Ruifang, LI Li, YANG Lei, LIU Liguo, YAN Guoyan   

  1. Zunhua People's Hospital,Zunhua 064200,Hebei,China
  • Received:2016-05-26 Online:2017-08-30 Published:2017-09-01

摘要:

目的 评估血小板(PLT)相关参数和骨髓巨核细胞计数、分类在May-Hegglin异常(MHA)和原发性免疫性血小板减少症(ITP)中的应用价值。方法 选取急性、慢性ITP患者88例,MHA疾病患者15例。同时选取正常对照者40名。分4个组进行巨核细胞计数、分类及PLT 4 项参数[PLT计数、血小板压积(PCT)、血小板平均体积(MPV)、血小板体积分布宽度(PDW)]检测,并作比较。结果 MHA组PDW 和MPV较急性ITP组、慢性ITP组、正常对照组显著增高(P<0.05); MHA组巨核细胞计数及分类与急、慢性ITP组比较差异有统计学意义(P<0.05),与正常对照组比较差异无统计学意义(P>0.05)。结论 MPV、PDW在MHA疾病诊断中具有较大价值;骨髓巨核细胞计数和分类可有效鉴别MHA与急、慢性ITP。

关键词: May-Hegglin异常, 巨核细胞, 原发性免疫性血小板减少症, 血小板参数

Abstract:

Objective To evaluate the roles of platelet (PLT)parameters and bone marrow megakaryocyte count and classification in May-Hegglin anomaly(MHA)and primary immune thrombocytopenia(ITP). Methods A total of 88 patients with acute and chronic primary ITP were enrolled,there were 15 patients with MHA,and 40 healthy subjects were enrolled as control group. They were classified into 4 groups,and megakaryocyte count and classification and 4 parameters of PLT [PLT count,plateletcrit(PCT),mean platelet volume(MPV)and platelet volume distribution width(PDW)] were determined. Results PDW and MPV were higher in MHA group than those in acute and chronic primary ITP group and control group(P<0.05). There was statistical significance for megakaryocyte count and classification in MHA group compared with those in acute and chronic primary ITP group (P<0.05),and there was no statistical significance compared with control group (P>0.05). Conclusions MPV and PDW play roles in the diagnosis of MHA. Megakaryocyte count and classification can identify MHA and acute and chronic primary ITP.

Key words: May-Hegglin anomaly, Megakaryocyte, Primary immune thrombocytopenia, Platelet parameter

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